arry her boyfriend, Colliar Sims.
More than twenty years later, M.E. and her husband still live in Birmingham, where they struggle to make ends meet. Their oldest son, Bobby, died as a child, but they have two more children, daughter Kelly and son Davis. Rene moved to Washington, D.C. where she was a successful attorney for many years, but after the death of her father, Rene decides to move back to Birmingham and establish a law practice there. She reunites with M.E. and the two quickly resume their close friendship. In every episode, contemporary storylines are interwoven with a storyline from their shared past.
Any Day Now focuses on the lives and interactions of two female protagonists: Mary Elizabeth "M.E." O'Brien Sims (Potts) and Rene Jackson (Toussaint). The two had grown up as close friends in Birmingham, Alabama in the 1960s during the peak of the civil rights movement. However, their friendship ended when M.E. became pregnant and chose, despite Rene's disapproval, to keep the child, drop out of college, and marry her boyfriend, Colliar Sims.
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